구강편평세포암종에서 p16발현과 PCNA 지수 및 임상병리학적 지표와의 상관관계
Expression of p16 in oral squamous cell carcinoma and its relation to PCNA index and clinicopathologic factors
한광흥, 이재일, 홍삼표, 홍성두, 임지준,
소속 상세정보
한광흥 ( ) - 서울대학교
이재일 ( ) - 서울대학교
홍삼표 ( ) - 서울대학교
홍성두 ( ) - 서울대학교
임지준 ( Lim Ji-Jun ) - 서울대학교 치과대학 구강병리학교실
KMID : 0829220050290020049
Abstract
The p16 gene encodes an inhibitor of the cyclin-dependent kinase, which inactivates cyclin-dependent kinase and controls the cell cycle progression. The loss of p16 expression or overexpression has been reported in many kinds of tumors. Both p16 and PCNA regulates cell cycle progression at the G1/S checkpoint. Although many researches about the p16 expression in oral cancer have been carried out, there are few studies about the correlation between p16 expression and proliferation of oral cancer cells. The object of this study was to evaluate the availability of p16 as early diagnostic factor and prognostic factor through correlation analysis of p16 expression in oral squamous cell carcinoma and its relation to PCNA index and clinicopathologic factors. So we investigated p16 immunohistochemical expression of 83 oral squmaous cell carcinomas, and obtained the results as followed. 18 out of the 83 cases(21.69%) showed p16 positive and 65 samples(78.31%) showed p16 negative. While the mean value of PCNA indices of p16 positive cases was 65.94±18.32, that of PCNA indices at p16 negative ones 54.79±18.39. This difference between them showed statistical significance.(P=0.030) p16 positive group was 12/60(20.0%) of well differentiated tumors and p16 negative group was 6/23(16.1%) of moderately or poorly differentiated tumors. This difference did not show statistical significance.(P=0.372) From the results above, it was suggested p16 expression is related to PCNA index in oral squamous cell carcinomas.
키워드
Oral squamous cell carcinomas;p16;PCNA index
원문 및 링크아웃 정보
등재저널 정보